Dose Effect - Revision history

Barb: /* Mental Health Dose Effect */

2025-08-21T17:24:35Z

Mental Health Dose Effect

← Older revision		Revision as of 12:24, 21 August 2025
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	==Mental Health Dose Effect==		==Mental Health Dose Effect==
	'''[http://onlinelibrary.wiley.com/doi/10.1111/1471-0528.13233/full Previous pregnancy loss has an adverse impact on distress and behaviour in subsequent pregnancy.] McCarthy F, Moss-Morris R, Khashan A, et al.BJOG An Int J Obstet Gynaecol. 2015;122(13):1757-1764. doi:10.1111/1471-0528.13233.'''		'''Auger N, Healy-Profitós J, Ayoub A, Lewin A, Low N. Induced abortion and implications for long-term mental health: a cohort study of 1.2 million pregnancies. J Psychiatr Res. 2025 Jul;187:304-310. doi: 10.1016/j.jpsychires.2025.05.031. Epub 2025 May 16. PMID: 40408979.'''


			'''[http://onlinelibrary.wiley.com/doi/10.1111/1471-0528.13233/full Previous pregnancy loss has an adverse impact on distress and behaviour in subsequent pregnancy.] McCarthy F, Moss-Morris R, Khashan A, et al.BJOG An Int J Obstet Gynaecol. 2015;122(13):1757-1764. doi:10.1111/1471-0528.13233.'''
	:Women with one previous termination displayed elevated perceived stress (adjusted mean difference 0.65; 95% CI 0.08–1.23) and depression (aOR 1.25; 95% 1.08–1.45) at 15 weeks of gestation. Women with two previous terminations displayed increased perceived stress (adjusted mean difference 1.43; 95% CI 0.00–2.87) and depression (aOR 1.67; 95% 1.28–2.18).		:Women with one previous termination displayed elevated perceived stress (adjusted mean difference 0.65; 95% CI 0.08–1.23) and depression (aOR 1.25; 95% 1.08–1.45) at 15 weeks of gestation. Women with two previous terminations displayed increased perceived stress (adjusted mean difference 1.43; 95% CI 0.00–2.87) and depression (aOR 1.67; 95% 1.28–2.18).

Barb at 21:28, 8 December 2016

2016-12-08T21:28:32Z

← Older revision		Revision as of 16:28, 8 December 2016
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	===Dose Effect Evidence===		=Dose Effect Evidence=

	====Mental Health Dose Effect====		==Mental Health Dose Effect==
	'''[http://onlinelibrary.wiley.com/doi/10.1111/1471-0528.13233/full Previous pregnancy loss has an adverse impact on distress and behaviour in subsequent pregnancy.] McCarthy F, Moss-Morris R, Khashan A, et al.BJOG An Int J Obstet Gynaecol. 2015;122(13):1757-1764. doi:10.1111/1471-0528.13233.'''		'''[http://onlinelibrary.wiley.com/doi/10.1111/1471-0528.13233/full Previous pregnancy loss has an adverse impact on distress and behaviour in subsequent pregnancy.] McCarthy F, Moss-Morris R, Khashan A, et al.BJOG An Int J Obstet Gynaecol. 2015;122(13):1757-1764. doi:10.1111/1471-0528.13233.'''
	:Women with one previous termination displayed elevated perceived stress (adjusted mean difference 0.65; 95% CI 0.08–1.23) and depression (aOR 1.25; 95% 1.08–1.45) at 15 weeks of gestation. Women with two previous terminations displayed increased perceived stress (adjusted mean difference 1.43; 95% CI 0.00–2.87) and depression (aOR 1.67; 95% 1.28–2.18).		:Women with one previous termination displayed elevated perceived stress (adjusted mean difference 0.65; 95% CI 0.08–1.23) and depression (aOR 1.25; 95% 1.08–1.45) at 15 weeks of gestation. Women with two previous terminations displayed increased perceived stress (adjusted mean difference 1.43; 95% CI 0.00–2.87) and depression (aOR 1.67; 95% 1.28–2.18).
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	====Physical Health Dose Effect====
			==Physical Health Dose Effect==
	'''[http://www.ncbi.nlm.nih.gov/pubmed/22933527 Birth outcomes after induced abortion: a nationwide register-based study of first births in Finland.] Klemetti R, Gissler M, Niinimäki M, Hemminki E. Hum Reprod. 2012 Nov;27(11):3315-20. doi: 10.1093/humrep/des294. Epub 2012 Aug 29.'''		'''[http://www.ncbi.nlm.nih.gov/pubmed/22933527 Birth outcomes after induced abortion: a nationwide register-based study of first births in Finland.] Klemetti R, Gissler M, Niinimäki M, Hemminki E. Hum Reprod. 2012 Nov;27(11):3315-20. doi: 10.1093/humrep/des294. Epub 2012 Aug 29.'''
	: After adjustment, perinatal deaths and very preterm birth (<28 gestational week) suggested worse outcomes after IA. Increased odds for very preterm birth were seen in all the subgroups and exhibited a dose-response relationship: 1.19 [95% confidence interval (CI) 0.98-1.44] after one IA, 1.69 (1.14-2.51) after two and 2.78 (1.48-5.24) after three IAs. Increased odds for preterm birth (<37 weeks) and low birthweight (<2500 g and <1500 g) were seen only among mothers with three or more IAs: 1.35 (1.07-1.71), 1.43 (1.12-1.84) and 2.25 (1.43-3.52), respectively.		: After adjustment, perinatal deaths and very preterm birth (<28 gestational week) suggested worse outcomes after IA. Increased odds for very preterm birth were seen in all the subgroups and exhibited a dose-response relationship: 1.19 [95% confidence interval (CI) 0.98-1.44] after one IA, 1.69 (1.14-2.51) after two and 2.78 (1.48-5.24) after three IAs. Increased odds for preterm birth (<37 weeks) and low birthweight (<2500 g and <1500 g) were seen only among mothers with three or more IAs: 1.35 (1.07-1.71), 1.43 (1.12-1.84) and 2.25 (1.43-3.52), respectively.

	====Life Expectancy/Elevated Mortality Rate Dose Effect====

			==Life Expectancy/Elevated Mortality Rate Dose Effect==

	'''[http://www.ncbi.nlm.nih.gov/pubmed/22954474 Reproductive history patterns and long-term mortality rates: a Danish, population-based record linkage study.] Coleman PK, Reardon DC, Calhoun BC. Eur J Public Health. 2012 Sep 5.'''		'''[http://www.ncbi.nlm.nih.gov/pubmed/22954474 Reproductive history patterns and long-term mortality rates: a Danish, population-based record linkage study.] Coleman PK, Reardon DC, Calhoun BC. Eur J Public Health. 2012 Sep 5.'''

	:Risk of death was more than six times greater among women who had never been pregnant compared with those who only had birth(s). Increased risks of death were 45%, 114% and 191% for 1, 2 and 3 abortions, respectively, compared with no abortions after controlling for other reproductive outcomes and last pregnancy age.		:Risk of death was more than six times greater among women who had never been pregnant compared with those who only had birth(s). Increased risks of death were 45%, 114% and 191% for 1, 2 and 3 abortions, respectively, compared with no abortions after controlling for other reproductive outcomes and last pregnancy age.

Barb at 21:27, 8 December 2016

2016-12-08T21:27:10Z

← Older revision		Revision as of 16:27, 8 December 2016
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	===Dose Effect Evidence===		===Dose Effect Evidence===

	====~~mental health dose effect~~====		====Mental Health Dose Effect====
	'''[http://onlinelibrary.wiley.com/doi/10.1111/1471-0528.13233/full Previous pregnancy loss has an adverse impact on distress and behaviour in subsequent pregnancy.] McCarthy F, Moss-Morris R, Khashan A, et al.BJOG An Int J Obstet Gynaecol. 2015;122(13):1757-1764. doi:10.1111/1471-0528.13233.'''		'''[http://onlinelibrary.wiley.com/doi/10.1111/1471-0528.13233/full Previous pregnancy loss has an adverse impact on distress and behaviour in subsequent pregnancy.] McCarthy F, Moss-Morris R, Khashan A, et al.BJOG An Int J Obstet Gynaecol. 2015;122(13):1757-1764. doi:10.1111/1471-0528.13233.'''
	:Women with one previous termination displayed elevated perceived stress (adjusted mean difference 0.65; 95% CI 0.08–1.23) and depression (aOR 1.25; 95% 1.08–1.45) at 15 weeks of gestation. Women with two previous terminations displayed increased perceived stress (adjusted mean difference 1.43; 95% CI 0.00–2.87) and depression (aOR 1.67; 95% 1.28–2.18).		:Women with one previous termination displayed elevated perceived stress (adjusted mean difference 0.65; 95% CI 0.08–1.23) and depression (aOR 1.25; 95% 1.08–1.45) at 15 weeks of gestation. Women with two previous terminations displayed increased perceived stress (adjusted mean difference 1.43; 95% CI 0.00–2.87) and depression (aOR 1.67; 95% 1.28–2.18).
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	====~~physical health dose effect~~====		====Physical Health Dose Effect====
	'''[http://www.ncbi.nlm.nih.gov/pubmed/22933527 Birth outcomes after induced abortion: a nationwide register-based study of first births in Finland.] Klemetti R, Gissler M, Niinimäki M, Hemminki E. Hum Reprod. 2012 Nov;27(11):3315-20. doi: 10.1093/humrep/des294. Epub 2012 Aug 29.'''		'''[http://www.ncbi.nlm.nih.gov/pubmed/22933527 Birth outcomes after induced abortion: a nationwide register-based study of first births in Finland.] Klemetti R, Gissler M, Niinimäki M, Hemminki E. Hum Reprod. 2012 Nov;27(11):3315-20. doi: 10.1093/humrep/des294. Epub 2012 Aug 29.'''
	: After adjustment, perinatal deaths and very preterm birth (<28 gestational week) suggested worse outcomes after IA. Increased odds for very preterm birth were seen in all the subgroups and exhibited a dose-response relationship: 1.19 [95% confidence interval (CI) 0.98-1.44] after one IA, 1.69 (1.14-2.51) after two and 2.78 (1.48-5.24) after three IAs. Increased odds for preterm birth (<37 weeks) and low birthweight (<2500 g and <1500 g) were seen only among mothers with three or more IAs: 1.35 (1.07-1.71), 1.43 (1.12-1.84) and 2.25 (1.43-3.52), respectively.		: After adjustment, perinatal deaths and very preterm birth (<28 gestational week) suggested worse outcomes after IA. Increased odds for very preterm birth were seen in all the subgroups and exhibited a dose-response relationship: 1.19 [95% confidence interval (CI) 0.98-1.44] after one IA, 1.69 (1.14-2.51) after two and 2.78 (1.48-5.24) after three IAs. Increased odds for preterm birth (<37 weeks) and low birthweight (<2500 g and <1500 g) were seen only among mothers with three or more IAs: 1.35 (1.07-1.71), 1.43 (1.12-1.84) and 2.25 (1.43-3.52), respectively.

	====~~life expectancy~~ / ~~elevated mortality rate dose effect~~====		====Life Expectancy/Elevated Mortality Rate Dose Effect====

	'''[http://www.ncbi.nlm.nih.gov/pubmed/22954474 Reproductive history patterns and long-term mortality rates: a Danish, population-based record linkage study.] Coleman PK, Reardon DC, Calhoun BC. Eur J Public Health. 2012 Sep 5.'''		'''[http://www.ncbi.nlm.nih.gov/pubmed/22954474 Reproductive history patterns and long-term mortality rates: a Danish, population-based record linkage study.] Coleman PK, Reardon DC, Calhoun BC. Eur J Public Health. 2012 Sep 5.'''

	:Risk of death was more than six times greater among women who had never been pregnant compared with those who only had birth(s). Increased risks of death were 45%, 114% and 191% for 1, 2 and 3 abortions, respectively, compared with no abortions after controlling for other reproductive outcomes and last pregnancy age.		:Risk of death was more than six times greater among women who had never been pregnant compared with those who only had birth(s). Increased risks of death were 45%, 114% and 191% for 1, 2 and 3 abortions, respectively, compared with no abortions after controlling for other reproductive outcomes and last pregnancy age.

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2016-12-08T21:25:51Z

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===Dose Effect Evidence===

====mental health dose effect====
'''[http://onlinelibrary.wiley.com/doi/10.1111/1471-0528.13233/full Previous pregnancy loss has an adverse impact on distress and behaviour in subsequent pregnancy.] McCarthy F, Moss-Morris R, Khashan A, et al.BJOG An Int J Obstet Gynaecol. 2015;122(13):1757-1764. doi:10.1111/1471-0528.13233.'''
:Women with one previous termination displayed elevated perceived stress (adjusted mean difference 0.65; 95% CI 0.08–1.23) and depression (aOR 1.25; 95% 1.08–1.45) at 15 weeks of gestation. Women with two previous terminations displayed increased perceived stress (adjusted mean difference 1.43; 95% CI 0.00–2.87) and depression (aOR 1.67; 95% 1.28–2.18).

'''[http://gorm.com.tr/index.php/GORM/article/view/521/484 Depression Following Induced Abortion.] Koyun, A., Kır Şahin, F., Çevrioğlu, S., Demirel, R., & Geçici, Ö. (2016). Gynecology Obstetrics & Reproductive Medicine, 13(2). doi:http://dx.doi.org/10.21613/GORM.2007.521'''
:Note. The researchers also observed a dose effect, with multiple abortions increasing depression risk.

'''[http://www.ncbi.nlm.nih.gov/pubmed/24007380 Increased risk for postpartum psychiatric disorders among women with past pregnancy loss.] Giannandrea SAM, Cerulli C, Anson E, Chaudron LH. J Womens Health (Larchmt) [Internet]. 2013;22(9):760–8. Available from: http://www.ncbi.nlm.nih.gov/pubmed/24007380 PMID: 24007380'''
:Multiple losses, either from miscarriage or induced abortion, predict elevated rates of postpartum anxiety.(2)

====physical health dose effect====
'''[http://www.ncbi.nlm.nih.gov/pubmed/22933527 Birth outcomes after induced abortion: a nationwide register-based study of first births in Finland.] Klemetti R, Gissler M, Niinimäki M, Hemminki E. Hum Reprod. 2012 Nov;27(11):3315-20. doi: 10.1093/humrep/des294. Epub 2012 Aug 29.'''
: After adjustment, perinatal deaths and very preterm birth (<28 gestational week) suggested worse outcomes after IA. Increased odds for very preterm birth were seen in all the subgroups and exhibited a dose-response relationship: 1.19 [95% confidence interval (CI) 0.98-1.44] after one IA, 1.69 (1.14-2.51) after two and 2.78 (1.48-5.24) after three IAs. Increased odds for preterm birth (<37 weeks) and low birthweight (<2500 g and <1500 g) were seen only among mothers with three or more IAs: 1.35 (1.07-1.71), 1.43 (1.12-1.84) and 2.25 (1.43-3.52), respectively.

====life expectancy / elevated mortality rate dose effect====

'''[http://www.ncbi.nlm.nih.gov/pubmed/22954474 Reproductive history patterns and long-term mortality rates: a Danish, population-based record linkage study.] Coleman PK, Reardon DC, Calhoun BC. Eur J Public Health. 2012 Sep 5.'''

:Risk of death was more than six times greater among women who had never been pregnant compared with those who only had birth(s). Increased risks of death were 45%, 114% and 191% for 1, 2 and 3 abortions, respectively, compared with no abortions after controlling for other reproductive outcomes and last pregnancy age.